![]() ![]() With some of these tiny creatures we share a mutually beneficial relationship, and they help to protect and nourish us in return for food and shelter. We are surrounded by billions of microbes, many of which live on or even inside us. melanogaster, we believe this new system will enable rapid progress in understanding how E. Given the vast molecular toolkit available for D. muscae invades the nervous system, suggesting a direct means by which the fungus could induce behavioral changes. ![]() muscae infection: hours before death, they climb upward, extend their proboscides, affixing in place, then raise their wings, clearing a path for infectious spores to launch from their abdomens. Lab-infected flies manifest the moribund behaviors characteristic of E. We recently discovered a strain of the behavior-manipulating fungal pathogen Entomophthora muscae infecting wild Drosophila, and established methods to infect D. Mechanistic understanding has been largely constrained by the lack of an experimental system amenable to molecular manipulation. Many microbes induce striking behavioral changes in their animal hosts, but how they achieve this is poorly understood, especially at the molecular level. ![]()
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